Pular para o conteúdo principal
Início

Dedicated to discovery

  • Sobre a ELGA
    • Sobre a ELGA
    • Carreiras
    • Eventos
  • Apoio
    • Planeamento laboratorial
  • Contacto
  • EN
  • DE
  • ES
  • FR
  • IT
  • EN-US
Início
  • Produtos
    • PURELAB
      • PURELAB® Dispenser
      • PURELAB® Flex
      • PURELAB® Quest
      • PURELAB® Pharma Compliance
      • PURELAB® Chorus 1 Complete
      • PURELAB® Chorus 1
      • PURELAB® Chorus 2
      • PURELAB® Chorus 3
      • PURELAB® Chorus 2 +
    • CENTRA
      • CENTRA® R60/120
      • CENTRA® R200
      • CENTRA® RDS
    • MEDICA
      • MEDICA® 150
      • MEDICA® 7/15
      • MEDICA® BIOX 2024
      • MEDICA® Pro-R & Pro-RE
      • MEDICA® R200
      • MEDICA® EDI 15/30
      • MEDICA® Pro-LPS
      • MEDICA® Pro EDI 60/120
      • MEDICA® BIOX
      • Hubgrade
    • BIOPURE
      • BIOPURE® 300/600
    • PURENERGY® 30
    • Gama completa dos produtos ELGA
  • Aplicações
    • Análise microbiológica
    • Bioquímica Clínica
    • Cromatografia gasosa
    • Cromatografia líquida
      • High Performance Liquid Chromatography
    • Culturas de célula
    • Eletroquímica
    • Espectrofotometria
    • Espectrometria de massa
    • Espectroscopia Atómica
    • Genética
    • High Performance Liquid Chromatography (HPLC)
    • Imunoquímica
    • Requisitos de água para laboratório em geral
  • Tecnologias
    • Carbono ativado
    • Eletrodeionização (EDI)
    • Filtração
    • Osmose Reversa
    • PureSure
    • Troca iónica
    • Ultravioleta
  • Impurezas na água
    • Compostos biológicos
    • Compostos inorgânicos
    • Gases dissolvidos
    • Microrganismos e bactérias
    • Partículas
  • Conhecimento
    • BROSCHÜREN
    • Blogue
    • Estudos de caso
    • Água ultrapura
    • Guias e Livros brancos
  • Where to buy
  • Contacto
Home
  • Contacto
  • Produtos
    • PURELAB
      • PURELAB® Dispenser
      • PURELAB® Flex
      • PURELAB® Quest
      • PURELAB® Pharma Compliance
      • PURELAB® Chorus 1 Complete
      • PURELAB® Chorus 1
      • PURELAB® Chorus 2
      • PURELAB® Chorus 3
      • PURELAB® Chorus 2 +
    • CENTRA
      • CENTRA® R60/120
      • CENTRA® R200
      • CENTRA® RDS
    • MEDICA
      • MEDICA® 150
      • MEDICA® 7/15
      • MEDICA® BIOX 2024
      • MEDICA® Pro-R & Pro-RE
      • MEDICA® R200
      • MEDICA® EDI 15/30
      • MEDICA® Pro-LPS
      • MEDICA® Pro EDI 60/120
      • MEDICA® BIOX
      • Hubgrade
    • BIOPURE
      • BIOPURE® 300/600
    • PURENERGY® 30
    • Gama completa dos produtos ELGA
  • Aplicações
    • Análise microbiológica
    • Bioquímica Clínica
    • Cromatografia gasosa
    • Cromatografia líquida
      • High Performance Liquid Chromatography
    • Culturas de célula
    • Eletroquímica
    • Espectrofotometria
    • Espectrometria de massa
    • Espectroscopia Atómica
    • Genética
    • High Performance Liquid Chromatography (HPLC)
    • Imunoquímica
    • Requisitos de água para laboratório em geral
  • Tecnologias
    • Carbono ativado
    • Eletrodeionização (EDI)
    • Filtração
    • Osmose Reversa
    • PureSure
    • Troca iónica
    • Ultravioleta
  • Impurezas na água
    • Compostos biológicos
    • Compostos inorgânicos
    • Gases dissolvidos
    • Microrganismos e bactérias
    • Partículas
  • Conhecimento
    • BROSCHÜREN
    • Blogue
    • Estudos de caso
    • Água ultrapura
    • Guias e Livros brancos
  • Where to buy
  • Contacto
  • Sobre a ELGA
    • Sobre a ELGA
    • Carreiras
    • Eventos
  • Apoio
    • Planeamento laboratorial
  • Contacto
  • EN
  • DE
  • ES
  • FR
  • IT
  • EN-US
  • Política de privacidade
  • Termos e condições
  • Conformidade legal global
  • Patentes
  • Trademarks
  • Impressum
  • Can 3D Printing Help Overcome Challenges With Drug Delivery?
Clinical & Pharma
Science of the Future

Can 3D Printing Help Overcome Challenges With Drug Delivery?

22 mar 2020
- by Dr Alison Halliday

Blood Pressure

Researchers demonstrate the potential advantages of using 3D UV inkjet printing to create tablet forms of a poorly soluble drug.


The low solubility of drug compounds is an increasing challenge in drug development. Estimates suggest that around 40% of approved drugs and nearly 90% of molecules in the discovery pipeline are poorly water-soluble, which can lead to low bioavailability and poor drug delivery. 

3D printing offers a precise and scalable new opportunity for the manufacturing of pharmaceuticals. Adjusting key parameters such as geometry and infill density could potentially help transform a poorly soluble drug into tablets with new rapid drug-releasing properties.

But to make use of these innovative new technologies, researchers need to develop liquid inks containing polymers, drugs and other materials that can be used to print tablets into the desired shape and then turned into a solid form. One way to achieve this is by developing formulations that can be solidified through exposure to UV light.

3D Printed Beta-Blockers

In a new study, a team of researchers formulate, print and characterise a UV ink for 3D inkjet printing and investigate the feasibility of using this to produce solid dosage forms of a poorly soluble drug.1 

Carvedilol is a beta-blocker used to treat high blood pressure and heart failure. Nearly insoluble in water, the drug is commercially available in a range of low dose immediate and sustained release doses. These formulations use the relatively poorly soluble crystalline solid-state forms of the active compound.

The team developed an ink formulation consisting of 10% (wt%) carvedilol within a photocurable matrix and used a 3D inkjet printer equipped with a UV lamp to create tablets with several different geometries – ring, mesh, cylinder, and thin film. By characterising the printed tablets using Raman and FTIR-ATR spectroscopy, they indicated that the drug was in an amorphous state with strong hydrogen bonding between the drug and the cross-linked matrix.

Drug Release Depends On The Geometry

The researchers analysed the drug release speed of the printed tablets using dissolution testing with high-performance liquid chromatography (HLPC). For these experiments, they used ultrapure water generated from an ELGA laboratory water purification system to minimise the risk of introducing contaminants that may affect their results.

The researchers found that more than 80% carvedilol was released from all of the different tablet geometries within ten hours. Drug release was fastest for the thin films, followed by the ring and mesh geometries, and slowest for the cylindrical dosage forms. They calculated that faster release was related to an increased surface area to volume ratio.

The Future Of Drug Manufacturing?

This is the first study to demonstrate the feasibility of 3D UV inkjet printing to make solid dispersion tablets for a poorly soluble drug. The results also demonstrate that different release profiles can be successfully achieved with a single ink formulation by varying tablet geometry.

Why Choose ELGA LabWater?

ELGA’s expert engineers, chemists and scientists are at the forefront of technological innovation. We continue to introduce game-changing features to the ultrapure laboratory water market.


Reference:

  1. Clark, E. A. et al. Making Tablets for Delivery of Poorly Soluble Drugs Using Photoinitiated 3D Inkjet Printing. International Journal of Pharmaceutics 2019; S0378-5173(19)30850-6.


Dr Alison Halliday
After completing an undergraduate degree in Biochemistry & Genetics at Sheffield University, Alison was awarded a PhD in Human Molecular Genetics at the University of Newcastle. She carried out five years as a Senior Postdoctoral Research Fellow at UCL, investigating the genes involved in childhood obesity syndrome. Moving into science communications, she spent ten years at Cancer Research UK engaging the public about the charity’s work. She now specialises in writing about research across the life sciences, medicine and health.

  • Sales Enquiry
  • Obter uma cotação
  • Technical Support
  • Encontre um parceiro aprovado

Sales Enquiry

At ELGA LabWater, we have exciting offers and news about our products and services that we hope you’d like to hear about. We will use your information to predict what you might be interested in. We will treat your data with respect and you can find the details in our Privacy Policy.

ELGA LabWater works with a network of Approved Partners. In order to answer your questions or enquiries, we may pass your contact details to an Approved Partner, who may contact you directly. 

I'd like to receive updates from ELGA LabWater & ELGA Approved Partners based on my details.

Obter uma cotação

At ELGA LabWater, we have exciting offers and news about our products and services that we hope you’d like to hear about. We will use your information to predict what you might be interested in. We will treat your data with respect and you can find the details in our Privacy Policy.

ELGA LabWater works with a network of Approved Partners. In order to answer your questions or enquiries, we may pass your contact details to an Approved Partner, who may contact you directly. 

I'd like to receive updates from ELGA LabWater & ELGA Approved Partners based on my details.

Technical Support

At ELGA LabWater, we have exciting offers and news about our products and services that we hope you’d like to hear about. We will use your information to predict what you might be interested in. We will treat your data with respect and you can find the details in our Privacy Policy.

ELGA LabWater works with a network of Approved Partners. In order to answer your questions or enquiries, we may pass your contact details to an Approved Partner, who may contact you directly. 

Call us

Can't find what you are looking for?

Support Number
+44 (0)20 3567 7300
United Kingdom Sales
+44 (0)1628 879 704
United States of America Sales
+1 877-315-3542
France Sales
+33 1 40 83 65 00
China Sales
+86 400-616-8882

 

Sede da ELGA LabWater

Lane End Business Park
Lane End, High Wycombe
HP14 3BY
Reino Unido
T: +44 (0) 203 567 7300
F: +44 (0) 203 567 7205

Estudos de caso

  • Abbott Diagnostics
  • DASA Medical Diagnostics
  • NeoDIN Medical Institute
  • North Staffordshire NHS Trust
  • Olsberg Vocational College

Recursos

  • Saber mais sobre água ultrapura
  • Guias e Livros Brancos
  • Tecnologias de purificação
  • Aplicações
  • Impurezas na água
  • Latest Blog
  • What is Total Organic Carbon (TOC)?
  • What is Clinical Laboratory Reagent Water (CLSI)?
  • Water Purity - Different Types of Pure Water

© VWS (UK) Ltd. negociando como ELGA LabWater.2025-Todos os direitos reservados.
ELGA é a marca global de água para laboratórios da Veolia.

  • Política de privacidade
  • Termos e condições
  • Conformidade legal global
  • Patentes
  • Trademarks
  • Impressum
  • Idioma
    • Deutsch
    • English
    • Español
    • Français
    • Italiano
    • Português
    • 日本語
    • 中文
  • Outros sítios Web da Veolia
    • Veolia
    • Veolia Foundation
    • Veolia Water Technologies
Elga Veolia
TOP

© 2017 ELGA Veolia